This project aims at deciphering the putative roles of prokineticin-2 (PK2), a recently identified neuro-peptide with key roles in the control of GnRH neuronal migration, maturation of the reproductive brain and the regulation of endogenous rhythms, in the regulation of the neuronal networks responsible for the control of the secretion of GnRH (major neuropeptide involved in the central activation of the reproductive axis). Special emphasis will be made in this project to elucidate the putative interplay of PK2 with the recently identified family of neuropeptides, kisspeptins, which are essential gatekeepers of puberty and fertility in mammals.

The group UCO is the coordinator of this Project. The research fellow associated to this project will conduct part of his activities at the UCO group (during the return phase of his fellowship), where he will continue his physiologic studies on the roles of PK2 in the control of the reproductive axis and its interactions with kisspeptins.

Implementation of this project will help to elucidate the physiological roles and eventual patho-physiological implications of PK2 in the regulation of the reproductive axis, including its implication in puberty and fertility. Our studies will target the eventual interaction between PK2 and kisspeptins, and will include also elucidation of the physiological roles of the related neuropeptide, neurokinin-B, in the control of GnRH secretion, puberty onset and reproductive function.

This project will provide novel physiological knowledge concerning the mechanisms governing key reproductive phenomena, including puberty and reproduction. Considering the increasing incidence of disturbances of puberty and fertility in the general population, it is expected that the results of this project will help to unveil part of the neuroendocrine and molecular basis for such alterations. While this information will be generated using suitable animal models, our results are tentatively posed with great translational interest, as to illustrate on the potential basis of human reproductive diseases.

Balance Energético y Función Reproductora

Code PAIDI: BIO-310

Manuel Tena Sempere. Coordinador. 

Universidad de Córdoba

Budget of Andalusian group: € 158,513.40

www.uco.es